Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a combined operation on an subterranean weapons facility in Syrian territory operated by the Islamic State group (IS), as stated by the British defence ministry.
The site, located using intelligence, was thought to be storing arms and explosives, the announcement noted, and was situated in mountainous terrain just above the ancient city of Palmyra in central Syria.
"Our aircraft used Paveway IV guided bombs to strike a number of approach shafts down to the depot... initial indications suggest the objective was successfully hit," the MoD said.
There was no indication of any civilian casualties in the strike late on Saturday and each participating jet returned to base without incident, the MoD added.
The British jets were backed up by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as ISIS - established extremist governance over significant areas in Iraq and Syria prior to its 2019 collapse.
"This operation underscores our UK leadership, and commitment to stand shoulder to shoulder with our partners, to stamp out any revival of Daesh and their harmful and extremist ideologies in the region," Britain's Defence Chief John Healey said.
UK warplanes have performed overwatch operations over Syria to "deter any efforts to regroup" of the group subsequent to its routing at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank every member of our armed forces who took part in this strike for their professionalism and their courage," Healey added. "They were part of numerous British personnel stationed over Christmas and New Year. This action, to take out terrorist threats who endanger our security, shows how British military are prepared to act, throughout the year, keeping Britain secure within its borders and strong abroad."
During December, the US military conducted what it termed a "large-scale strike" targeting Daesh sites in the country, subsequent to an assault claimed the lives of two US troops and a local interpreter in Palmyra.
The United Nations says IS still maintains between 5,000 and 7,000 militants in Syria and Iraq.